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The risk or severity of adverse effects can be increased when Fluvoxamine is combined with Harmaline. Renal or hepatic insufficiency may cause elevated drug levels of both glyburide and metformin hydrochloride, and the hepatic insufficiency may also diminish gluconeogenic capacity, both of which increase the risk of hypoglycemic reactions. The majority of adverse reactions occurring during the studies were mild and generally did not require discontinuation of therapy. Ofloxacin Use During Pregnancy Drugs. The metabolism of Ranitidine can be decreased when combined with Mexiletine. Nowadays CP requires a prescription to purchase legitimately, making it more difficult to obtain.